Improving AAV and LV upstream manufacturing using cGMP lipid polymer nanocomplexes (LPNCs) from is a formulation a mixture Watch Video

⏲ Duration: 20 min 23 sec
✓ Published: 06-Jun-2023

Description:
With success of cell and gene therapies and exponentially increasing demand, the second wave of viral vector manufacturing is focused on large-scale suspension cell culture and/or adherent cell culture within intensified fixed bed bioreactors. In response to this need, Mirus Bio developed a novel HEK 293 cGMP cell transfection technology that increases AAV and LV titers 2-10-fold over existing technologies. The transfection reagent formulation is a mixture of lipid and polymer which enables the