Study Suggests Amygdala Response Can Predict Depression Treatment Outcomes from interview video recording equipment Watch Video

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✓ Published: 29-Jun-2024

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Study Suggests , Amygdala Response , Can Predict Depression Treatment Outcomes.<br/>'PsyPost' reports that a recent study found that people <br/>with major depressive disorder with lower amygdala <br/>activation are less likely to experience improvement. .<br/>'PsyPost' reports that a recent study found that people <br/>with major depressive disorder with lower amygdala <br/>activation are less likely to experience improvement. .<br/>The findings could help develop personalized treatment <br/>plans for people with depression by identifying patients <br/>who are less likely to respond to standard treatment.<br/>The findings could help develop personalized treatment <br/>plans for people with depression by identifying patients <br/>who are less likely to respond to standard treatment.<br/>The low success rate of initial <br/>treatment underscores the need <br/>for personalized treatment plans. .<br/>Recording functional MRI signal whilst <br/>seeing pictures of facial expressions of <br/>emotions has been used widely to detect <br/>an unconscious bias towards negative <br/>versus positive emotional stimuli <br/>in anxious individuals with <br/>and without depression, Roland Zahn, senior author and a professor <br/>of mood disorders and cognitive neuroscience <br/>at King’s College London, via 'PsyPost'.<br/>According to the results, a person's lower bilateral <br/>amygdala activation in response to seeing sad versus <br/>happy faces predicted poorer clinical outcomes.<br/>After four moths of standard treatment, participants <br/>with a weaker amygdala response to seeing <br/>happy faces were less likely to see improvement.<br/>After four moths of standard treatment, participants <br/>with a weaker amygdala response to seeing <br/>happy faces were less likely to see improvement.<br/>'PsyPost' reports that the findings suggest that the brain's <br/>ability to process positive emotions may play a critical <br/>role in recovery outcomes for patients with depression.<br/>We confirmed our prediction based <br/>on previous research that people with <br/>a weaker amygdala response to positive <br/>relative to negative facial expressions <br/>were less likely to improve their <br/>depressive symptoms after four months, Roland Zahn, senior author and a professor <br/>of mood disorders and cognitive neuroscience <br/>at King’s College London, via 'PsyPost'.<br/>The team behind the study suggests<br/>treatments be developed that enhance the<br/>brain's natural response to positive stimuli. .<br/>The findings were detailed in a study published in the journal 'Psychological Medicine.'