GREECS 2022 - Age acquired skewed X Chromosome Inactivation is associated with adverse health outcomes in humans from factor 10 assay Watch Video

⏲ Duration: 15 min 74 sec
✓ Published: 28-Jan-2022

Description:
Presented by Amy Robertsn---nAgeing is a heterogenous process characterised by cellular and molecular hallmarks, including changes to haematopoietic stem cells, and is a primary risk factor for chronic diseases. X chromosome inactivation (XCI) is a mammalian process which randomly transcriptionally silences either the maternal or paternal X in each cell of XX,46 females to balance the gene expression with XY,46 males. Age acquired XCI-skew describes the preferential inactivation of one of the tw