Ethical Considerations in Adaptive Design Clinical Trials from ethical case analysis Watch Video
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⏲ Duration: 35 min 28 sec ✓ Published: 24-Nov-2015
Description: BackgroundnnAdaptive design is generally accepted as an advance in clinical trial methodology, but trials planned and executed with AD present special challenges for observing the Belmont Report’s ethical principles in research involving human subjects.nMethodsnnWe review the features of particular design adaptations and discuss the ethical obstacles they present, and potentially resolve. We use examples of published and unpublished AD clinical trials, some successful and some less than succes